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The standard dosage for oral Benadryl for dogs is 1 mg per pound of body weight, given 2-3 times a day. Most diphenhydramine tablets are 25 mg, which is the size used for a 25-pound dog. But the safest way to give the proper dose is to ask your veterinarian.
Children’s Benadryl pills or tablets can also be used to dose very small dogs. Dosage for liquid Benadryl is different than the dosage for Benadryl pills.
The usual dosage of Benadryl for dogs is 1 mg/lb every 8 to 12 hours (two to three times daily). In certain situations (e.g. following a snake bite) 2 mg/lb per dose may be given instead. When used for allergies, it is best if the medicine is given before exposure to the allergen.
Like most medications, the given dose is based on the dog's body weight. The standard Benadryl dosage for dogs is one mg/pound of body weight. Available over-the-counter, most Benadryl tablets are 25 mg each--but it is important to always check the label ( a children's Benadryl might be best for small dogs).
Lethal dose of Benadryl in dogs “The lethal dose (LD 50 ) for diphenhydramine in dogs ranges between 24 to 30 mg/kg BW by IV administration, and death has been attributed to neuromotor excitement and convulsions, followed by respiratory failure and myocardial depression.” [ 3 ]
The dosage of Benadryl for dogs is 1 mg/lb given every 8 hours (three times a day). For example, a dog weighing 40 lbs would need 40 mg of Benadryl per dose. Benadryl, or diphenhydramine, is commonly prescribed by vets when a dog is suffering from allergies, or as a preventative measure for motion sickness if you’re planning on travelling with your pet.