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  • Cetirizine

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    Cetirizine, sold under the brand name Zyrtec among others, is a second-generation antihistamine used to treat hay fever, allergies, angioedema, and urticaria. It acts as a selective antagonist of the histamine H1 receptor. Second-generation antihistamines like cetirizine are less able to cross the blood–brain barrier and therefore have diminished effects on the central nervous system compared to first-generation drugs. Because of this, they are less likely to cause drowsiness or memory impairment. In 2016 it was the 74th most prescribed medication in the United States with more than 10 million prescriptions.

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