Web Results
  • Cushing's syndrome - Wikipedia

    en.m.wikipedia.org/wiki/Cushing's_syndrome

    Cushing's syndrome is caused by either excessive cortisol-like medication such as prednisone or a tumor that either produces or results in the production of excessive cortisol by the adrenal glands. Cases due to a pituitary adenoma are known as Cushing's disease. It is the second most common cause of Cushing's syndrome after medication.

  • Cushing's disease - Wikipedia

    en.m.wikipedia.org/wiki/Cushing's_disease

    Cushing's disease is one cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone from the anterior pituitary. This is most often as a result of a pituitary adenoma or due to excess production of hypothalamus CRH that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously administered corticosteroids. This should not be confus

  • Pseudo-Cushing's syndrome - Wikipedia

    en.m.wikipedia.org/wiki/Pseudo-Cushing's_syndrome

    Pseudo-Cushing's syndrome is a medical condition in which patients display the signs, symptoms, and abnormal hormone levels seen in Cushing's syndrome.However, pseudo-Cushing's syndrome is not caused by a problem with the hypothalamic-pituitary-adrenal axis as Cushing's is; it is mainly an idiopathic condition, however a cushingoid appearance is sometimes linked to excessive alcohol consumption.

  • Cushing's syndrome - Wikipedia Republished // WIKI 2

    wiki2.org/en/Cushing's_syndrome

    Cushing's syndrome is caused by either excessive cortisol-like medication such as prednisone or a tumor that either produces or results in the production of excessive cortisol by the adrenal glands. Cases due to a pituitary adenoma are known as Cushing's disease. It is the second most common cause of Cushing's syndrome after medication.

  • Cushing - Wikipedia

    en.m.wikipedia.org/wiki/Cushing

    Cushing's disease, an endocrine disorder (one of several specific causes of Cushing's syndrome) Cushing's syndrome, an endocrine disorder (an umbrella term for several disorders, including Cushing's disease and related disorders) Cushing reflex, in response to brain ischemia Cushing's triad, a clinical triad.

  • Talk:Cushing's syndrome - Wikipedia

    en.m.wikipedia.org/wiki/Talk:Cushing's_syndrome

    Cushing's syndrome is a collection of symptoms which can arise from an endocrine disorder, or, more often, as a side-effect of medication. Cushing’s Disease is a rare condition which causes a raised level of cortisol in the body, resulting in endogenous Cushing’s syndrome.

  • Cushing syndrome Disease Reference Guide - Drugs.com

    www.drugs.com/mcd/cushing-syndrome

    Cushing syndrome can develop from a cause outside of your body (exogenous Cushing syndrome). One example is taking oral corticosteroid medications in high doses over an extended period of time. These medications, such as prednisone, have the same effect in the body as does cortisol produced by your body.

  • Cushing Syndrome | Hypercortisolism | MedlinePlus

    medlineplus.gov/cushingssyndrome.html

    Cushing's syndrome is a hormonal disorder. The cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. Sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to Cushing's. Some kinds of tumors produce a hormone that can cause your body to make too much cortisol. Cushing's syndrome is rare.

Content Results
  • Osilodrostat

    serch.it?q=Osilodrostat

    Osilodrostat (INN, USAN) (developmental code name LCI-699) is an orally active, nonsteroidal corticosteroid biosynthesis inhibitor which is under development by Novartis for the treatment of Cushing's syndrome and pituitary hypersecretion (a specific subtype of Cushing's syndrome). It specifically acts as a potent and selective inhibitor of aldosterone synthase (CYP11B2) and at higher dosages of 11β-hydroxylase (CYP11B1). The drug was also under development for the treatment of heart failure, hypertension, and solid tumors, but development was discontinued for these indications. As of 2017, osilodrostat is in phase III and phase II clinical trials for treatment of pituitary ACTH hypersecretion and Cushing's syndrome, respectively.

  • Acanthosis nigricans

    serch.it?q=Acanthosis-nigricans

    Acanthosis nigricans is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead, and other areas.

  • Apparent mineralocorticoid excess syndrome

    serch.it?q=Apparent-mineralocorticoid-excess-syndr

    Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the HSD11B2 gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate the mineralocorticoid receptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in the kidney. This is what causes the hypokalemia, hypertension, and hypernatremia associated with the syndrome. Patients often present with severe hypertension and end-organ changes associated with it like left ventricular hypertrophy, retinal, renal and neurological vascular changes along with growth retardation and failure to thrive. In serum both aldosterone and renin levels are low

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