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Metastasize definition is - to spread or grow by or as if by metastasis. How to use metastasize in a sentence.
Metastasize definition, (of malignant cells or disease-producing organisms) to spread to other parts of the body by way of the blood or lymphatic vessels or membranous surfaces. See more.
Define metastasize. metastasize synonyms, metastasize pronunciation, metastasize translation, English dictionary definition of metastasize. intr.v. me·tas·ta·sized , me·tas·ta·siz·ing , me·tas·ta·siz·es 1. To be transmitted or transferred by metastasis. 2. To be changed or transformed,...
Metastasis: 1. The process by which cancer spreads from the place at which it first arose as a primary tumor to distant locations in the body. 2. The cancer resulting from the spread of the primary tumor. For example, someone with melanoma may have a metastasis in their brain, while a person with colon cancer might, fortunately, have no metastases.
Metastasis (plural, metastases) The spread of disease from one part of the body to another, as when cancer cells appear in parts of the body remote from the site of the primary tumor.
The spread of cancer cells from the place where they first formed to another part of the body. In metastasis, cancer cells break away from the original (primary) tumor, travel through the blood or lymph system, and form a new tumor in other organs or tissues of the body.
Metastasis means that cancer spreads to a different body part from where it started. When this happens, doctors say the cancer has “metastasized.” Your doctor may also call it "metastatic cancer," "advanced cancer," or "stage 4 cancer."
METASTASES: CT scan of liver (upper left) with round metastatic tumors (Courtesy of Harvey Hatch, MD, Curry General Hospital) 2. Change in location of a disease or of its manifestations or transfer from one organ or part to another not directly connected.
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues. Cancer occurs after cells are genetically altered to proliferate rapidly and indefinitely. This uncontrolled proliferation by mitosis produces a primary heterogeneic tumour. The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a malignant phenotype. This malignancy allows for invasion into the circulation, followed by invasion to a second site for tumorigenesis. Some cancer cells known as circulating tumor cells acquire the ability to penetrate the walls of lymphatic or blood vessels, after which they are able to circulate through the bloodstream to other sites and tissues in the body. This process is known (respectively) as lymphatic or hematogenous spread.
Common sites of metastasis for breast cancerMetastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease has spread to distant sites beyond the axillary lymph nodes. There is no cure for metastatic breast cancer. There is no stage after IV. It usually occurs several years after the primary breast cancer, although it is sometimes diagnosed at the same time as the primary breast cancer or, rarely, before the primary breast cancer has been diagnosed. Metastatic breast cancer cells frequently differ from the preceding primary breast cancer in properties such as receptor status. The cells have often developed resistance to several lines of previous treatment and have acquired special properties that permit them to metastasize to distant sites. Metastatic breast cancer can be treated, sometimes for many years, but it cannot be cured. Distant metastases are the cause of about 90% of deaths due to breast cancer.
A pre-metastatic niche is an environment in a secondary organ conducive to the metastasis of a primary tumor. Such a niche provides favorable conditions for growth, and eventually metastasis, in an otherwise foreign and hostile environment for the primary tumor cells. The discovery of the pre-metastatic niche has fostered new research regarding the potential treatment of metastases, including attempts to stop the flow of vesicles from primary tumors to pre-metastatic niches in secondary organs and different combinations of previously-employed therapies.