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  • Renin–angiotensin system

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    Anatomical diagram of RAS The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that regulates blood pressure and fluid balance. When renal blood flow is reduced, juxtaglomerular cells in the kidneys convert the precursor prorenin (already present in the blood) into renin and secrete it directly into circulation. Plasma renin then carries out the conversion of angiotensinogen, released by the liver, to angiotensin I. Angiotensin I is subsequently converted to angiotensin II by the angiotensin-converting enzyme (ACE) found on the surface of vascular endothelial cells, predominantly those of the lungs. Angiotensin II is a potent vasoconstrictive peptide that causes blood vessels to narrow, resulting in increased blood pressure. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. Aldosterone causes the renal tubules to increase the reabsorption of sodium and water into the blood, while at the same time causing the excretion of potassium (to maintain electrolyte balance). This increases the volume of extracellular fluid in the body, which also increases blood pressure.

  • Kiss Me, Judas

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    Kiss Me, Judas is a 1998 neo-noir novel by the American author Will Christopher Baer. The book was first published on October 1, 1998, through Viking Press and follows the character of Phineas Poe after he wakes up in a hotel bathtub full of ice to discover that somebody has removed one of his kidneys.

  • Search Party (film)

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    Search Party is a 2014 American comedy film directed by Scot Armstrong in his directorial debut, and co-written with Mike Gagerman and Andrew Waller based on a story by Gagerman and Waller. The film stars T.J. Miller, Adam Pally, Thomas Middleditch, Alison Brie, Shannon Woodward, and Krysten Ritter. The film was released in 2014 internationally, but was not released in the United States until May 13, 2016, by Focus World.

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