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  • Melflufen

    serch.it?q=Melflufen

    Melflufen (melphalan flufenamide, previously designated J1) is an anticancer drug under development by Oncopeptides AB. It is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. Aminopeptidase N plays a functional role in malignant angiogenesis. Currently, melflufen is under evaluation in a multinational and randomized phase III study for the treatment of patients with relapsed and refractory multiple myeloma.

  • Windows Movie Maker

    serch.it?q=Windows-Movie-Maker

    Windows Movie Maker (formerly known as Windows Live Movie Maker in Windows 7) was a video editing software by Microsoft. It was a part of Windows Essentials software suite and offered the ability to create and edit videos as well as to publish them on OneDrive, Facebook, Vimeo, YouTube, and Flickr. Movie Maker was officially discontinued on January 10, 2017 and it is replaced by Windows Story Remix which is built in with Microsoft Photos in Windows 10.

  • Macrophage activation syndrome

    serch.it?q=Macrophage-activation-syndrome

    Macrophage-activation syndrome (MAS) is a severe, potentially life-threatening, complication of several chronic rheumatic diseases of childhood. It occurs most commonly with systemic-onset juvenile idiopathic arthritis (SoJIA). In addition, MAS has been described in association with systemic lupus erythematosus (SLE), Kawasaki disease, and adult-onset Still's disease. It is thought to be closely related and pathophysiologically very similar to reactive (secondary) hemophagocytic lymphohistiocytosis (HLH). The incidence of MAS is unknown as there is a wide spectrum of clinical manifestations, and episodes may remain unrecognized.

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