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But some people experience side effects. The most common statin side effects include: Headache. Difficulty sleeping. Flushing of the skin. Muscle aches, tenderness, or weakness (myalgia) Drowsiness. Dizziness.
Some drugs that may interact with statins and increase your risk of side effects include: Amiodarone (Cordarone, Pacerone), a medication for irregular heart rhythms. Gemfibrozil (Lopid), another variety of cholesterol drug. HIV treatments called protease inhibitors such as saquinavir (Invirase) ...
How to relieve statin side effects Take a brief break from statin therapy. Switch to another statin drug. Change your dose. Take it easy when exercising. Consider other cholesterol-lowering medications. Try coenzyme Q10 supplements.
Statins Side Effect #1: Muscle Pain It’s not uncommon for us to feel aches and pains in our muscles. Quite often, it is a case of our muscles being overworked or just having been in the same position for too long.
Side Effects of Statins Short-Term Side Effects. Here are some side effects of statins that you may experience as soon as you start taking them: Headache; Muscle aches and tenderness; Sleep disorders; Drowsiness; Dizziness; Pain in the abdomen and cramping; Flushing of the skin; Nausea and vomiting; Diarrhea; Constipation; Rash; Mental confusion; Hyperglycemia (high blood sugar levels) Memory loss (rare) Long Term Side Effects Of Statins
Common side effects of all statins. Side effects reported by some people include muscle pain and digestive problems. Muscle pain is the most common side effect caused by statin use. A 2005 study found that over 10 percent of people taking high-dose statins had muscle pain. Muscle pain can be uncomfortable.
Uncommon side effects of statins (which may affect up to 1 in 100 people) include: being sick. loss of appetite or weight gain. difficulty sleeping (insomnia) or having nightmares. dizziness – if you experience this, do not drive or use tools and machinery. loss of sensation or tingling in the ...
Muscle Pain, Myopathy, and Rhabdomyolysis. Muscle symptoms are a common side effect of statins; many people experience aches in the shoulders, pain in the jaw, or muscle pain in the legs. The pain indicates muscle breakdown. When tissues break down, the body must eliminate waste products.
Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications. Statins have been found to reduce cardiovascular disease and mortality in those who are at high risk of cardiovascular disease. The evidence is strong that statins are effective for treating cardiovascular disease in the early stages of the disease (secondary prevention) and in those at elevated risk but without cardiovascular disease (primary prevention). Side effects of statins include muscle pain, increased risk of diabetes mellitus, and abnormalities in liver enzyme tests. Additionally, they have rare but severe adverse effects, particularly muscle damage. They inhibit the enzyme HMG-CoA reductase which plays a central role in the production of cholesterol. High cholesterol levels have been associated with cardiovascular disease. , a number of statins are on the market: atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. In 2005, sales were estimated at US$18.7billion in the United States. The best-selling statin is atorvastatin also known as Lipitor, which in 2003 became the best-selling pharmaceutical in history. The manufacturer Pfizer reported sales of US$12.4billion in 2008. Due to patent expirations, several statins became available in 2016 as less expensive generics.
Atorvastatin, sold under the trade name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. For the prevention of cardiovascular disease statins are a first line treatment. It is taken by mouth. Common side effects include joint pain, diarrhea, heart burn, nausea, and muscle pains. Serious side effects may include rhabdomyolysis, liver problems, and diabetes. Use during pregnancy may harm the baby. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver that plays a role in producing cholesterol. Atorvastatin was approved for medical use in the United States in 1996. It is avaliable as a generic medication. In the United States the wholesale cost per month is about 3.80 USD as of 2018. In the United Kingdom it costs about £28 per month as of 2018. In 2016 it was the 3rd most prescribed medication in the United States with more than 96 million prescriptions.
Simvastatin, marketed under the trade name Zocor among others, is a lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid (fat) levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth. Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels. Common side effects include constipation, headaches, and nausea. A lower dose may be needed in people with kidney problems. There is evidence of harm to unborn babies when taken during pregnancy and it should not be used by those who are breastfeeding. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Simvastatin was developed by Merck and came into medical use in 1992. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is US$0.01 to 0.12 per day . In the United States it costs between US$0.50 and 1.00 per day. Simvastatin is made from the fungus Aspergillus terreus. In 2016 it was the 8th most prescribed medication in the United States with more than 65 million prescriptions.