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The most common cause of low MCHC is anemia. Hypochromic microcytic anemia commonly results in low MCHC. This condition means your red blood cells are smaller than usual and have a decreased level of hemoglobin. This type of microcytic anemia can be caused by: lack of iron.
Low-Grade Blood Loss: Blood loss due to long menstrual cycle or peptic ulcers can also lead to low levels of MCHC. 5. Other Causes: Certain medical disorders like cancer, lead poisoning and parasitic infections like hookworm infection, may also be the responsible sources.
The following types of anemia are associated with a low hemoglobin concentration: Iron deficiency anemia. This condition can be caused by an iron-deficient diet or by an inability to absorb iron. When less iron is available for red blood cell development, the red blood cells become smaller and paler.
Causes of Low MCHC. Causes shown below are commonly associated with low MCHC. Work with your doctor or other health care professional to get an accurate diagnosis of the underlying cause. 1) Iron Deficiency. One of the most common causes of low MCHC is iron deficiency and iron deficiency anemia [6, 5]. Iron is necessary to produce hemoglobin, so if you are deficient in iron, you will produce less hemoglobin for each given red blood cell.
Treatment of MCHC Levels. When the cause of having low levels of MCHC is determined by a doctor, a suitable treatment plan is put in place. The commonest cause of low levels of MCHC is anemia that is associated with iron deficiency. In treating iron deficiency anemia, a doctor will recommend treatment options such as: 6
What Causes Low Hemoglobin Concentration in Red Blood Cells? Most cases of low MCHC (also called hypochromic MCHC) are caused by anemia. This is a medical condition in which there is a deficiency of red cells or of hemoglobin in the blood.
Low MCHC Causes. The MCHC blood test forms an important part of the blood analysis, and the MCHC value helps doctors recognize the cause and severity of anemia. Low MCHC test results indicate anemia which may be caused by normal physiological conditions such as pregnancy, or sometimes, life-threatening conditions such as cancer.
Low mean corpuscular hemoglobin concentration, or MCHC, may mean hypochromic anemia, according to MedlinePlus. A normal MCHC is 32 to 36 grams per deciliter. Lead poisoning, inflammation and iron deficiency can all cause hypochromic anemia. It can also be caused by a disease called thalassemia.
Hypochromic anemia, or Hypochromic anaemia, is a generic term for any type of anemia in which the red blood cells (erythrocytes) are paler than normal. (Hypo- refers to less, and chromic means color.) A normal red blood cell will have an area of pallor in the center of it; it is biconcave disk shaped. In hypochromic cells, this area of central pallor is increased. This decrease in redness is due to a disproportionate reduction of red cell hemoglobin (the pigment that imparts the red color) in proportion to the volume of the cell. Clinically the color can be evaluated by the Mean Corpuscular Hemoglobin (MCH) or Mean Corpuscular Hemoglobin Concentration (MCHC). The MCHC is considered the better parameter of the two as it adjusts for effect the size of the cell has on its color. Hypochromia is clinically defined as below the normal MCH reference range of 27-33 picograms/cell in adults or below the normal MCHC reference range of 33-36 g/dL in adults. Red blood cells will also be small (microcytic), leading to substantial overlap with the category of microcytic anemia. The most common causes of this kind of anemia are iron deficiency and thalassemia. Hypochromic anemia was historically known as chlorosis or green sickness for the distinct skin tinge sometimes present in patients, in addition to more general symptoms such as a lack of energy, shortness of breath, dyspepsia, headaches, a capricious or scanty appetite and amenorrhea.
Vitamin B12 deficiency anemia, of which pernicious anemia is a type, is a disease in which not enough red blood cells are produced due to a deficiency of vitamin B12. The most common initial symptom is feeling tired. Other symptoms may include shortness of breath, pale skin, chest pain, numbness in the hands and feet, poor balance, a smooth red tongue, poor reflexes, depression and confusion. Without treatment some of these problems may become permanent. Pernicious anemia refers to anemia that results from lack of intrinsic factor. Lack of intrinsic factor is most commonly due to an autoimmune attack on the cells that create it in the stomach. It can also occur following the surgical removal of part of the stomach or from an inherited disorder. Other causes of low vitamin B12 include not enough dietary intake (such as in a vegan diet), celiac disease, or tapeworm infection. When suspected, diagnosis is made by blood and, occasionally, bone marrow tests. Blood tests may show fewer but larger red blood cells, low numbers of young red blood cells, low levels of vitamin B12, and antibodies to intrinsic factor. Because pernicious anemia is due to a lack of intrinsic factor, it is not preventable. Vitamin B12 deficiency due to other causes may be prevented with a balanced diet or with supplements. Pernicious anemia can be easily treated with either injections or pills of vitamin B12. If the symptoms are severe, injections are typically recommended initially. For those who have trouble swallowing pills, a nasal spray is available. Often, treatment is lifelong. Pernicious anemia due to autoimmune problems occurs in about one per 1000 people. Among those over the age of 60, about 2% have the condition. It more commonly affects people of northern European descent. Women are more commonly affected than men. With proper treatment, most people live normal lives. Due to a higher risk of stomach cancer, those with pernicious anemia should be checked regularly for this. The first clear description was by Thomas Addison in 1849. The term "pernicious" means "deadly", and was used as before the availability of treatment the disease was often fatal.
hemoglobin The Mean corpuscular hemoglobin concentration, a measure of the concentration of haemoglobin in a given volume of packed blood. It is calculated by dividing the haemoglobin by the haematocrit. Reference ranges for blood tests are 32 to 36 g/dL (320 to 360g/L), or between 4.81 and 5.58 mmol/L. It is thus a mass or molar concentration. Still, many instances measure MCHC in percentage (%), as if it were a mass fraction (mHb / mRBC). Numerically, however, the MCHC in g/dL and the mass fraction of haemoglobin in red blood cells in % are identical, assuming an RBC density of 1g/mL and negligible haemoglobin in plasma.