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If you have vitamin B12 deficiency, you could become anemic. A mild deficiency may cause no symptoms. But if untreated, it may lead to symptoms such as: Weakness, tiredness, or lightheadedness. Heart palpitations and shortness of breath. Pale skin. A smooth tongue. Constipation, diarrhea, loss of appetite, or gas.
Vitamin B12 is a nutrient that helps keep the body's nerve and blood cells healthy and helps make DNA, the genetic material in all cells. Vitamin B12 also helps prevent a type of anemia called megaloblastic anemia that makes people tired and weak. Two steps are required for the body to absorb vitamin B12 from food.
Folate is needed for the synthesis of red blood cells (the tiny disc-shaped cells that deliver oxygen to every corner of your body), but vitamin B12 is required for a reaction that converts folate into a form the body can use to make those red blood cells.
Vitamin B12 does multiple things for our body. It ensures proper function and health of brain, nerve tissue and production of red blood cells. Vitamin B12 also helps in regulation and synthesis of DNA along with helping with the metabolism of the body.
Nervous System. Vitamin B-12 helps your body make and maintain healthy nerve cells. While vitamin B-12 deficiency is not common, even slightly low levels can cause abnormal neurological symptoms. A deficiency may result in nerve disturbances, such as muscle weakness, shaky movements or tingling in the hands and feet.
Well, the first hint is in the name: Vitamin B12 is, in fact, a vitamin. That means it’s essential for us to live, according to registered dietitian Amy Shapiro . But beyond that, vitamin B12 is known to help with our nervous system, blood-cell formation, digestion, and brain function, and helps prevent anemia and enhance our moods (so it also helps stave off depression, she noted).
Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal surface of the tongue (loss of the lingual papillae), leaving a smooth and erythematous (reddened) surface, (sometimes specifically termed atrophic glossitis). In a wider sense, glossitis can mean inflammation of the tongue generally. Glossitis is often caused by nutritional deficiencies and may be painless or cause discomfort. Glossitis usually responds well to treatment if the cause is identified and corrected. Tongue soreness caused by glossitis is differentiated from burning mouth syndrome, where there is no identifiable change in the appearance of the tongue, and there are no identifiable causes.
Methylmalonic acid (MMA) (conjugate base methylmalonate) is a dicarboxylic acid that is a C-methylated derivative of malonate. The coenzyme A linked form of methylmalonic acid, methylmalonyl-CoA, is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B12 as a cofactor. In this way, it enters the Krebs cycle, and is thus part of one of the anaplerotic reactions.
In enzymology, a vitamin B12-transporting ATPase () is an enzyme that catalyzes the chemical reaction ATP + H2O + vitamin B12out ADP + phosphate + vitamin B12inThe 3 substrates of this enzyme are ATP, H2O, and vitamin B12, whereas its 3 products are ADP, phosphate, and vitamin B12. This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (vitamin B12-importing). This enzyme participates in abc transporters - general.