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ALS is a progressive disease, which means it gets worse over time. It affects nerves in your brain and spinal cord that control your muscles. As your muscles get weaker, it gets harder for you to ...
Overview. Amyotrophic lateral sclerosis (a-my-o-TROE-fik LAT-ur-ul skluh-ROE-sis), or ALS, is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control.
ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. A-myo-trophic comes from the Greek language. "A" means no. "Myo" refers to muscle, and "Trophic" means nourishment – "No muscle nourishment."
ALS is short for amyotrophic lateral sclerosis. You might also have heard it called Lou Gehrig's disease, after the baseball player who was diagnosed with it in the 1930s.
Amyotrophic lateral sclerosis (ALS) is a group of rare neurological diseases that mainly involve the nerve cells (neurons) responsible for controlling voluntary muscle movement. Voluntary muscles produce movements like chewing, walking, and talking.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease, is a disease that affects parts of the nervous system that control voluntary muscle movements (the muscles that people move at will, like those of the arms and legs).
This is a list of notable people who have or had amyotrophic lateral sclerosis (ALS). Astrophysicist Stephen Hawking, whose ALS was diagnosed in 1963, had ALS for 55 years, the longest recorded time. Raymond Abrashkin – author Zeca Afonso – Portuguese folk singer and anti-fascist politician Derek Bailey – British avant-garde guitar virtuoso Jason Becker – American guitar virtuoso Lead Belly – blues singer and guitarist Stefano Borgonovo – Italian football player Rob Borsellino – Des Moines Register columnist and author of So I'm Talkin' to This Guy... Scott Brazil – American television producer and director O.J. Brigance – American football player and Advisor Donna Britt - Newscaster At WAFB in Baton Rouge Louisiana for more than 30 years Harry Browne – best-selling author and 2-time Libertarian U.S. presidential candidate Ben Byer - American playwright and subject of the film Indestructible, documenting his life post-diagnosis Jeff Capel II – American collegiate and professional basketball coach Paul Cellucci – politician and diplomat; 69th Governor of Massachusetts and U.S. Ambassador to Canada Ezzard Charles – boxer; former world heavyweight champion Leonard Cheshire – notable RAF pilot and charity worker Marián Čišovský – Slovak football player Dwight Clark – American football player Preston Cloud – eminent American earth scientist Sid Collins – radio personality; radio voice of the Indianapolis 500 Luca Coscioni – Italian researcher, political activist and advocate for euthanasia Ronnie Corbett - British comedian and actor Neale Daniher – former AFL player (Essendon) & coach (Melbourne) Stephen Darby - former footballer for Bolton Wanderers Dennis Day – singer, comedian, actor Dieter Dengler – Vietnam era Air Force pilot who escaped from Laotian POW camp Michael Donnelly – Gulf War veteran Peter Doohan - Australian tennis player Ann Downer – Author of books for children and teenagers Constantinos Apostolou Doxiadis – Greek architect, urban planner and visionary John Drury – longtime ABC7 Chicago news anchor Bruce Edwards – PGA Tour caddie for golfer Tom Watson Jenifer Estess – theatre producer; star of HBO documentary Three Sisters, subject of HBO film Jennifer; founding member of Project ALS Hal Finney – computer scientist Jay S. Fishman – Chairman of the Board and former CEO of The Travelers Companies Roberto Fontanarrosa – Argentine cartoonist Pete Frates – former Boston College baseball star, founder and inspiration behind the viral ALS Ice Bucket Challenge (Summer 2014) Steven Gey- law professor and expert on the separation of church and state and freedom of speech; former on-air analyst for ABC during the 2000 presidential recount Lou Gehrig – baseball player, after whom the disease is commonly referred Richard Glatzer – writer and director; director of Still Alice Steve Gleason – American football player for the New Orleans Saints 2000-2007 Jérôme Golmard - French tennis player Tim Green - Former NFL player and broadcaster. Stanislav Gross – former Prime Minister of the Czech Republic Marc Harrison – designer Pro Hart – Australian painter Stephen Hawking – theoretical physicist and author of several books on astrophysics, including A Brief History of Time Bob Haymes – actor, singer, pianist and songwriter of the Great American Songbook ballad "That's All" Stephen Heywood – carpenter; subject of So Much So Fast and His Brother's Keeper Stephen Hillenburg – marine biologist and cartoonist; creator of SpongeBob SquarePants Jim "Catfish" Hunter – baseball player Jörg Immendorff, German painter Jacob K. Javits, U.S. Senator from New York Axel Jensen – writer Jimmy Johnstone, Scottish international footballer Tony Judt – historian and writer Hans Keller – Austrian-born British musicologist and music critic. Motoo Kimura – Japanese population geneticist Suna Kıraç, Turkish businesswoman and philanthropist Dan Klein – Singer of The Frightnrs Mao Zedong – Chairman of the Chinese Communist Party Denny Miller- actor Charles Mingus – jazz bass player Glenn Montgomery – NFL football player for the Houston Oilers and Seattle Seahawks Augie Nieto – fitness guru; founder and retired chief executive of Life Fitness and the chairman of Octane Fitness David Niven – actor Krzysztof Nowak, Polish footballer Richard K. Olney – neurologist; ALS physician and researcher Sidney Preston Osborn – former governor of Arizona Neon Park – American artist Mike Porcaro- American bassist, Toto Diane Pretty – British "right to die" advocate Tony Proudfoot - CFL player, teacher, coach, broadcaster and journalist. Don Revie – English football player and manager Fernando Ricksen – Dutch football player Sue Rodriguez – Canadian "right to die" advocate Franz Rosenzweig – philosopher and religious thinker Ayan Sadakov - Bulgarian football player and manager Stanley Sadie – British musicologist, music critic and editor of the New Grove Dictionary of Music and Musicians Ed Sadowski – baseball catcher and coach Washington César Santos – Brazilian Footballer. Michael Schwartz – key conservative political strategist in the U.S. Congress; American "right to life" advocate; chief of staff to U.S. Senator Tom Coburn, M.D. (R-Okla.) Morrie Schwartz – educator Raúl Sendic – Uruguayan Marxist and leader of the Tupamaros Sam Shepard - American actor and playwright Gianluca Signorini – Italian football player Lane Smith – actor Konrad Spindler – archaeologist, involved in the analysis of the Ötzi glacier mummy Jon Stone – creator of Sesame Street Maxwell D. Taylor – former chairman of the Joint Chiefs of Staff Orlando Thomas- NFL safety for the Minnesota Vikings Kevin Turner – NFL fullback for the New England Patriots and Philadelphia Eagles Roy Walford – gerontologist and life extensionist Henry A. Wallace – 33rd Vice President of the United States to Franklin D. Roosevelt Charlie Wedemeyer – former athlete and coach; motivational speaker Doddie Weir – former Scottish rugby union player Joost van der Westhuizen – former South African Rugby Union player; former Supersport commentator Michael Zaslow – soap actor Catherine G. Wolf - American psychologist and expert in human-computer interaction
Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles. Some also use the term motor neuron disease for a group of conditions of which ALS is the most common. ALS is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size. This results in difficulty speaking, swallowing, and eventually breathing. The cause is not known in 90% to 95% of cases. The remaining 5–10% of cases are inherited from a person's parents. About half of these genetic cases are due to one of two specific genes. The underlying mechanism involves damage to both upper and lower motor neurons. The diagnosis is based on a person's signs and symptoms, with testing done to rule out other potential causes. No cure for ALS is known. A medication called riluzole may extend life by about two to three months. Non-invasive ventilation may result in both improved quality and length of life. The disease can affect people of any age, but usually starts around the age of 60 and in inherited cases around the age of 50. The average survival from onset to death is two to four years. About 10% survive longer than 10 years. Most die from respiratory failure. In much of the world, rates of ALS are unknown. In Europe the disease affects about two to three people per 100,000 per year. Descriptions of the disease date back to at least 1824 by Charles Bell. In 1869, the connection between the symptoms and the underlying neurological problems was first described by Jean-Martin Charcot, who in 1874 began using the term amyotrophic lateral sclerosis. It became well known in the United States in the 20th century when in 1939 it affected the baseball player Lou Gehrig and later worldwide following the 1963 diagnosis of cosmologist Stephen Hawking. In 2014, videos of the Ice Bucket Challenge went viral on the Internet and increased public awareness of the condition.
Primary lateral sclerosis (PLS) is a rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles. PLS belongs to a group of disorders known as motor neuron diseases. Motor neuron diseases develop when the nerve cells that control voluntary muscle movement degenerate and die, causing weakness in the muscles they control. PLS only affects upper motor neurons. There is no evidence of the degeneration of spinal motor neurons or muscle wasting (amyotrophy) that occurs in amyotrophic lateral sclerosis (ALS).