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Possible benefits of CoQ10 supplements. Taking CoQ10 supplements can help increase your CoQ10 levels and may reduce statin side effects. Study results of the benefits of CoQ10 for reducing muscle pain associated with statin use are conflicting, however.
CoQ10 — also known as ubiquinone — is a coenzyme that helps muscles produce the energy they need to do their work. While some studies have suggested that statins can reduce the amount of CoQ10 in muscle tissue, other studies have not found a decrease in CoQ10 levels with statins.
They found that taking statins significantly lowered blood CoQ10 levels. And this was the case for all four types of statins studied. Blood CoQ10 levels were depleted the most with rosuvastatin (Crestor®) and simvastatin (Zocor®) followed by pravastain (Provochol®) and atorvastin (Lipitor®).
CoQ10 can be taken at the same time as statin medication. However, regular CoQ10 is fat-soluble, so it is best absorbed with foods that contain fats. Some statins are better absorbed when taken without food, so, if yours is one of them, it would be better to take CoQ10 separately with a meal that contains fats or oils (preferably unsaturated fats or oil, as these are better for your cardiovascular system).
The depletion of CoQ10 caused by the drug is why statins can increase your risk of acute heart failure. So if you're taking a statin drug, you MUST take Coenzyme Q10 as a supplement. If you're over 40, I would strongly recommend taking ubiquinol instead of CoQ10, as it's far more effectively absorbed by your body.
CoQ10 And Statins – It Makes Sense to Supplement with CoQ10 This vital coenzyme is so essential to the body that you’ll notice immediately if you’re in short supply. Because statins can rob your body of this vital component, it makes sense to supplement your diet with CoQ10.
Atorvastatin, sold under the trade name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. For the prevention of cardiovascular disease statins are a first line treatment. It is taken by mouth. Common side effects include joint pain, diarrhea, heart burn, nausea, and muscle pains. Serious side effects may include rhabdomyolysis, liver problems, and diabetes. Use during pregnancy may harm the baby. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver that plays a role in producing cholesterol. Atorvastatin was approved for medical use in the United States in 1996. It is avaliable as a generic medication. In the United States the wholesale cost per month is about 3.80 USD as of 2018. In the United Kingdom it costs about £28 per month as of 2018. In 2016 it was the 3rd most prescribed medication in the United States with more than 96 million prescriptions.
Coenzyme Q10, also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10 , CoQ, or Q10 is a coenzyme that is ubiquitous in animals and most bacteria (hence the name ubiquinone). It is a 1,4-benzoquinone, where Q refers to the quinone chemical group and 10 refers to the number of isoprenyl chemical subunits in its tail. This fat-soluble substance, which resembles a vitamin, is present in all respiring eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, which generates energy in the form of ATP. Ninety-five percent of the human body's energy is generated this way. Therefore, those organs with the highest energy requirements—such as the heart, liver, and kidney—have the highest CoQ10 concentrations. There are three redox states of CoQ10: fully oxidized (ubiquinone), semiquinone (ubisemiquinone), and fully reduced (ubiquinol).